Mitochondrial DNA Haplogroups and Delirium During Sepsis

Mitochondrial DNA Haplogroups and Neurocognitive Impairment During HIV Infection.

BACKGROUND Neurocognitive impairment (NCI) remains an important complication in persons infected with human immunodeficiency virus (HIV). Ancestry-related mitochondrial DNA (mtDNA) haplogroups have been associated with outcomes of HIV infection and combination antiretroviral therapy (CART), and with neurodegenerative diseases. We hypothesize that mtDNA haplogroups are associated with NCI in HIV...

Mitochondrial Haplogroups and Well Defined Populations

Mitochondrial DNA haplogroups and age-related hearing loss.

OBJECTIVE To determine whether variants of the mitochondrial genome influence the risk of developing age-related hearing loss (ARHL). DESIGN Cross-sectional study. SETTING Eligible participants were noninstitutionalized permanent residents 49 years or older identified in a door-to-door census of 2 suburban postcode areas, west of Sydney, Australia. PARTICIPANTS The Blue Mountains Hearing ...

Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis.

MITOCHONDRIAL DNA AND AGEING Osteoarthritis (OA) is the most common form of arthritis affecting more than 12% of people over the age of 60. Although late-onset articular cartilage degeneration is common and age is one of the most important risk factors for the disease, the relationship between old age and OA is not fully understood. In the past it was believed that the link with age was due to ...

CURRENTOPINION Mitochondrial DNA in Sepsis

Purpose of review Our understanding of critical illness is transforming as we develop a better understanding of the impact pathogen-associated molecular patterns and damage-associated molecular patterns (DAMPs) have on the pathogenesis of disease. Of the known DAMPs, there is a growing interest in mitochondrial DNA (mtDNA) as a DAMP capable of propagating the inflammatory response seen in sepsi...